Ozenoxacin Cream In Impetigo: Early Recovery,Faster Resolution: It’s Dosage,Indications And Contraindications O

Ozenoxacin Cream In Impetigo: Early Recovery,Faster Resolution: It's Dosage,Indications And Contraindications
OZENOXACIN

 Ozenoxacin is a new promising drug for impetigo management. It is available in 1% cream w/w.Each gram of tube contains 10 mg of Ozenoxacin. 

Ozenoxacin is indicated for the topical treatment of impetigo due to Staphylococcus aureus or streptococcus pyogenes in adult and pediatric patients from 2 months of age. 

How to apply  Ozenoxacin cream in impetigo 

  • Apply a thin layer of  Ozenoxacin cream topically to the affected area twice daily for 5 days.
  •    Patients not showing clinical response within three days should be reevaluated and alternative treatment should be considered. 
  • Wash hands after applying  ozenoxacin cream
  • Ozenoxacin cream is only for topical applications 
  • Never use for oral, ophthalmic, intravaginal, and intranasal.


The treatment area should be preferably covered with a sterile bandage.


Special warning and precautions for use of Ozenoxacin 

  • The prolonged use may result in the overgrowth of non-susceptible bacteria or fungi.
  • Sensitization or severe local irritation may occur sometimes after applying ozenoxacin cream. In such cases, treatment should be discontinued and alternative treatment should be considered. 
  • Ozenoxacin cream must be kept away from the eyes’ mucous membranes. 
  • Especially in children, care must be taken to avoid ingestion.
  • Ozenoxacin cream contains Benzoic acid which may be irritant to mucous membranes, eyes, and skin and may increase jaundice in premature babies.

Is Ozenoxacin is safe in pregnancy and lactation 

Till now there is no available data on the use of Ozenoxacin in pregnant women and lactating mothers. However systemic absorption of Ozenoxacin is negligible following topical administration of Ozenoxacin in impetigo. Due to the negligible absorption, it is not expected that it will do any harm to the baby.

Is Ozenoxacin cream in impetigo is safe for children 

Yes, the safety and efficiency of Ozenoxacin in the treatment of impetigo have been established well between the age group of 2 months to 17 years.
It has been seen that the safety and effectiveness of Ozenoxacin cream in pediatric age group 2 months to 17years are the same as adults. 
There is no study available for the age group below 2 months of age. 

Antimicrobial  properties of Ozenoxacin 

Ozenoxacin inhibits bacterial DNA replication enzymes, DNA gyrase A and topoisomerase IV.
Ozenoxacin cream is characterized by its potency and bactericidal activity against clinical bacterial isolates involved in skin infections including Staphylococcus aureus and streptococcus pyogenes. 
The proposed epidemiological cut-off (ECOFF) values for Staphylococcus aureus and streptococcus pyogenes are of .008 and .06 microgram/ ml.

Ozenoxacin has the lowest MIC 

Amongst all available topical antimicrobial cream Ozenoxacin has the lowest MIC values for Staphylococcus aureus and streptococcus pyogenes. 

Take-Home Message 

Ozenoxacin is safe and effective in the treatment of impetigo in adults as well as children. 

Ozenoxacin has the lowest MIC against streptococcus pyogenes and Staphylococcus aureus amongst all available topical antimicrobial. 

Always wash hands after using Ozenoxacin cream. 

It is not for oral, ophthalmic, intravaginal, and intranasal applications.

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